This article problematizes the delimitations of the Triple Helix approach concerning social aspects of innovation and entrepreneurship by acknowledging the engagement of a wider range of actors and sectors in such processes of change. Instead, the article explores the potential of the Quadruple Helix approach to help identify soci(et)al needs, envision inclusive social and economic renewal, and develop innovative measures for attaining those visions. As a response to the delimited focus of the Triple Helix, the Quadruple Helix adds civil sector actors to the already acknowledged private, public and academic sector actors. The article uses three case studies from Sweden and Mexico to demonstrate how a wider range of actors and sectors can be included in processes of soci(et)al innovation and entrepreneurship. The authors were involved in the cases in a dual role of activists and researchers in line with a participatory research approach. This results distinguish how the Quadruple Helix approach serves to facilitate socially inclusive regional development by enabling the involved actors to contribute to social innovation both as professionals and volunteers to initiate tailor-made solutions for social ventures, and universities to encourage scholars and students to intertwine theoretical development and soci(et)al change.