All humans desire to have a good quality of life i.e. living in relation to their goals, expectations, standards and concerns in life. The quality of life is related to healthy lifestyle, therefore, practicing health behavior is crucial for children and adolescents as the habits developed in early life persist in later life. However, in the contemporary world it has become quite a challenge to practice health behavior due to exposure to technology, electronic devices and social media which has adversely affected two important components of health behavior i.e. sleep and vigorous physical activity. This study aimed at investigating the impact of sleep duration during school days and vigorous physical activity during the week on quality of life. The data collected from 7700 students aged 11,13 & 15 from Swedish schools within the HSBC study in 2014. ANOVA, linear regression and mean comparison were used to test the hypotheses. The results show that age, gender, long-term disability and physical activity effects the sleep duration of children and adolescents. Moreover, children and adolescents who sleep longer hours and do vigorous physical activities have a higher quality of life. Sleep duration have also been found to be associated with a higher quality of life.