Introduction:During the course of their disease, persons with multiple sclerosis experience restrictions to their mobility that impact on their occupational engagement. Little is known about how persons with multiple sclerosis experience the transition from manual to power wheelchair. Aim:To describe how persons with multiple sclerosis experience the transition from a manual to a power wheelchair, and how this transition affects their occupational engagement. Method: Five persons with multiple sclerosis who had transitioned to a power wheelchair within the previous 36 months participated in semi-structured interviews. The interviews were analysed through qualitative content analysis supported by the framework of the Canadian Model of Occupational Performance and Engagement. Findings:Transition to a power wheelchair improved the participants’ ability to get around, their comfort sitting, and fatigue level. These improvements led to increased occupational engagement, primarily related to leisure activities. The timing of the transition was perceived as an important aspect. Conclusions: A gradual introduction to a power wheelchair earlier in the disease course could facilitate acceptance and help maintain occupational engagement. Significance: The occupational therapist has an important role in raising an early dialogue to find the right timing and processes for transition to power wheelchair to support occupational engagement.