The collected data included socio-demographic information and measurements of health literacy, e-health literacy, men-tal well-being, and sleep hygiene behaviors. The study aimed to provide insights regarding health literacy status and re-lated factors in the general population residing in Qazvin province, Iran. The findings of the study will assist health au-thorities and policy makers in developing and implementing effective interventions, which in turn, improving health lit-eracy in the community. Additionally, the findings can also aid health sector workers, including non-communicable dis-ease researchers, public health experts, health education spe-cialists, epidemiologists, and sociologists, in their work to improve health literacy and overall health outcomes among general population. Therefore, the present study used paper-pencil method with multi-stage cluster sampling to collect data. Trained research associates (n = 25) collected data from9775 people living in Qazvin province between January and April 2022. All the participants completed the study ques-tionnaires using self-reported paper-pencil mode.