The widespread use of social media platforms and the emergence of influencer marketing have revolutionized brand-consumer interactions, particularly among the younger demographic. In line with this trend, the influence of e-cigarette influencers on Generation Z (Gen Z) has become a prominent area of research. As influencer marketing continues to thrive and the e-cigarette industry experiences significant growth, it is imperative to comprehend how these influencers shape Gen Z's perception of influencers endorsing e-cigarette brands. Therefore, this study aims to examine the perception of Gen Z towards Instagram influencers in the United States who endorse e-cigarette brands. By exploring the perspectives of Gen Z, this research seeks to gain insights into the potential impact of these influencers on Gen Z's attitudes and behaviours regarding e-cigarettes. The study was based on the theory of source credibility and celebrity endorsement. The study adopted a qualitative research approach and employed in-depth interviews and netnography as methodology. A total of eleven in-depth interviews were conducted with participants from Gen Z who possessed knowledge and familiarity with e- cigarettes. Additionally, through netnography, comments from publicly available Instagram posts of the selected e-cigarette influencers were collected and examined over a period of three years. The findings highlight that Gen Z generally holds a positive perception of e-cigarette influencers on Instagram, perceiving them as credible sources of information and inspiration, thereby influencing their attitudes and behaviours concerning e-cigarettes. These insights have practical implications for e-cigarette brands aiming to engage Gen Z through influencer marketing, emphasizing the importance of trust and expertise in influencer-generated content. However, the study also highlights potential societal implications, including the potential for i increased e-cigarette consumption and ethical concerns surrounding the influence of trustworthy influencers on underage users. In conclusion, the study proposes avenues for future research, such as conducting surveys with larger sample sizes and exploring perceptions of e- cigarette influencers on alternative social media platforms like TikTok.