Infographics are a widely used tool for presenting information in a clear and visually concise format. They are frequently used within health and medical communication, something that has become increasingly more common to access online in this digital era. However, individuals with dyslexia often face challenges in reading and processing standard visual content. This study investigated how applying dyslexia-friendly design principles to digital health infographics affected information retention among dyslexic individuals compared to non dyslexia-friendly designs. An experimental, quantitative research design was used with 10 dyslexic participants (experimental group) and 10 non-dyslexic participants (control group). All participants viewed a dyslexia-friendly infographic and a non dyslexia-friendly infographic, and were then presented with a quiz to assess their ability to recall information from the infographics. The collected data were analyzed using paired- and independent-samples t-tests. The results showed that both groups remembered more from the non dyslexia-friendly designed infographic. These findings suggested that content familiarity and visual salience may play a larger role in information retention than adherence to accessibility design principles alone. It also indicated that infographics by nature may already be sufficiently accessible for people with dyslexia.