The resource based radical change from semiconductor manufacturing into the artificial plant factory is studied by understanding the resource capabilities in each industry separately. Due to lack of scientific research in the resource re-utilization process, the phenomenon is explored by studying the role of three different resources from a holistic view. By a qualitative research method, the motivating reasons for the change, the resources involved in the change, duration, and the resource based information were studied. The collected data are analysed under three different categories such as knowledge, infrastructure, and production technology. The identified problems were the unsatisfied resource capabilities, which have to be solved during the change process. As a result of the analysis, a framework is developed by combining all the three resources from a holistic view, in the change process. The framework is structured in three separate phases and inferred to support the resource re-utilization in the radical change process.