Efficient support of business needs, processes and strategies by information technology is a key for successful enterprise functioning. The challenge of Business and IT Alignment (BITA) has been acknowledged and actively discussed by academics and practitioners during more than two decades. On one hand, in order to achieve BITA it is required to analyze an enterprise from multiple perspectives. On the other hand, it is also required to deal with multiple points of views of involved stakeholders and create a shared understanding between them. In relation to both of these needs EM is considered as a useful practice, as it allows representation of various focal areas of an enterprise and facilitates consensus-driven discussion between involved stakeholders. Various focal areas of an enterprise are linked to various domains that BITA include, for example, time and function focal areas from the Zachman Framework contribute to analysis of business domain of BITA. This and other interrelations are investigated in this study, which is done by conceptual positioning of Zachman’s focal areas on Information System strategy triangle and Generic Framework for Information Management.